I. Ulwazi olusisiseko
Igama eliqhelekileyo: Semaglutide
Uhlobo: I-GLP-1 receptor agonist (i-glucagon-efana ne-peptide-1 analog)
Inkqubo yoLawulo: Isitofu esingaphantsi kwesikhumba (kanye ngeveki)
II. Izalathisi kunye neMeko yokuVunywa kweKhaya
Izalathisi ezivunyiweyo
Uhlobo lwesi-2 loNyango lweSifo seswekile (Ivunywe yi-NMPA):
Umthamo: 0.5 mg okanye 1.0 mg, kanye ngeveki.
Izenzo: Ilawula i-glucose yegazi kunye nokunciphisa umngcipheko we-cardiovascular.
Ukutyeba ngokugqithisileyo/Unyango lokutyeba ngokugqithisileyo
III. Ubuchule bokuSebenza kunye nokuSebenza
I-Core Mechanism: Yenza i-GLP-1 isebenze ii-receptors, ilibazise ukuphuma kwesisu, kwaye yonyusa ukuhlutha.
Isebenza kwiziko le-hypothalamic appetite, inhibiting appetite.
Iphucula ubuntununtunu be-insulin kwaye ilawula imetabolism.
Ukusebenza kokuLahla kobunzima (Ngokusekwe kulingo lwezonyango lwamazwe ngamazwe):
Umyinge wokulahleka kwesisindo kwiiveki ze-68: 15% -20% (ngokubambisana neendlela zokuphila).
Izigulana ezingezizo isifo seswekile (BMI ≥ 30 okanye ≥ 27 eneengxaki):
Izigulane zesifo seswekile: Isiphumo esincinci sokunciphisa umzimba (malunga ne-5% -10%).
IV. Abemi abaSebenzisayo kunye neZithintelo
Abemi abaSebenzisayo
IMigangatho yeHlabathi (jonga kwi-WHO):
BMI ≥ 30 (utyebe);
I-BMI ≥ 27 kunye noxinzelelo lwegazi, isifo sikashukela, okanye ezinye izifo ze-metabolic (ubunzima obukhulu).
Ukuziqhelanisa kwasekhaya: Kufuna uvavanyo lukagqirha; okwangoku isetyenziswa kakhulu ekulawuleni ubunzima kwizigulane ezineswekile.
Contraindications
Imbali yomntu okanye yentsapho ye-medullary thyroid carcinoma (MTC);
Uninzi lwe-endocrine neoplasia syndrome uhlobo lwe-2 (MEN2);
abasetyhini abakhulelweyo okanye abancancisayo;
Izifo ezinzima zesisu (njengembali ye-pancreatitis).
V. Iziphumo ezisecaleni kunye neengozi
Iziphumo ebezingalindelekanga eziqhelekileyo (iziganeko> 10%):
Isicaphucaphu, ukuhlanza, isifo sohudo, ukuqunjelwa (kuncitshiswa ngokusetyenziswa ixesha elide).
Ukunciphisa ukutya, ukukhathala.
Imingcipheko emikhulu:
I-Thyroid C-cell tumors (imingcipheko eboniswe kwizifundo zezilwanyana, engekacaci ebantwini);
I-pancreatitis, isifo se-gallbladder;
I-Hypoglycemia (isilumkiso esifunekayo xa isetyenziswe ngokudibanisa nezinye i-hypoglycemic agents).
VI. Ukusetyenziswa kwangoku eTshayina
Iindlela zokuFumana:
Unyango lwesifo seswekile: Umyalelo ovela kwisibhedlele esiqhelekileyo.
Unyango lokuLahla kobunzima: Ifuna uvavanyo olungqongqo ngugqirha; amasebe eendocrinology kwizibhedlele ezithile eziphakamileyo angayimisela.
Iingozi ezivela kwiMijelo Engagunyaziswanga: Iziyobisi ezithengwa kusetyenziswa amajelo angekho semthethweni zisenokuba zezomgunyathi okanye zigcinwe ngendlela engafanelekanga, nto leyo ebeka imingcipheko yokhuseleko.
VII. Iingcebiso zokuSebenza
Landela ngokungqongqo uMmiselo kaGqirha: Sebenzisa kuphela emva kokuba ugqirha evavanye izikhombisi zemetabolism kunye nembali yosapho yonyango.
Ungenelelo lwendlela yokuphila edibeneyo: Amayeza kufuneka adityaniswe nokulawulwa kokutya kunye nokuzivocavoca ukuze kufumaneke iziphumo ezilungileyo.
Ukujongwa kwexesha elide: Jonga rhoqo umsebenzi we-thyroid, i-pancreatic enzymes, kunye nesibindi kunye nomsebenzi wezintso.
Ixesha lokuposa: Nov-03-2025