Kuphuhliso olunomdla oluhlaziya intsimi yokhathalelo lwempilo, iRaloxifene Hydrochloride, iyeza elitsha elikumgangatho ophezulu, liye langena kwiimarike, linika ukhetho lokutshintsha umdlalo kwiimeko zempilo ezahlukeneyo kunye nokuphucula kakhulu umgangatho wobomi.Eli candelo loxubo mayeza lifumene ukuqondwa ngokukhawuleza ngenxa yesakhono salo esimangalisayo ekujonganeni noluhlu olubanzi lweenkxalabo zempilo, ngakumbi kwabasetyhini.
Esinye sezicelo eziphambili zeRaloxifene Hydrochloride kukuthintela kunye nokunyangwa kwe-osteoporosis kubasetyhini be-postmenopausal.Uphando lubonise ukuba eli liyeza lisebenza ngokukodwa ekunciphiseni ukulahleka kwethambo kunye nokuphucula ukuxinana kwamathambo.I-Osteoporosis, imeko ebonakaliswe ngokunciphisa ukuxinana kwamathambo, ibeka umngcipheko omkhulu wokuphuka, ngakumbi kubasetyhini abadala.Ngokusungulwa kwe-Raloxifene Hydrochloride, izigulane ngoku zifikelela kumlingane onamandla ekulweni nemiba enxulumene namathambo, ekugqibeleni ukunciphisa umngcipheko wokuphuka kunye nokuphucula impilo yethambo jikelele.
Nangona kunjalo, uphando olutshanje lubonise ukuba impembelelo yeRaloxifene Hydrochloride idlulela ngaphaya konyango lwe-osteoporosis.Iyeza libonise amandla athembisayo ekuthinteleni umhlaza webele ohlaselayo kubasetyhini abasemva kokuya exesheni abane-osteoporosis, kunye nokunciphisa umngcipheko wokuba nomhlaza webele we-estrogen receptor-positive.Oku kufunyaniswayo kuzisa ithemba elitsha kwizigulana kunye nabasebenzi bezempilo ngokufanayo, kugxininisa ukubaluleka kwamayeza akumgangatho ophezulu ekuguquleni imeko yothintelo kunye nonyango lomhlaza wamabele.
Ngapha koko, indlela ekhethekileyo yeRaloxifene Hydrochloride ibonelela ngezibonelelo ezongezelelweyo kwizigulana.Ngokungafaniyo nonyango lokubuyisela ihomoni yesiNtu, eli yeza alinazo iziphumo ezibi ezidla ngokunxulunyaniswa ne-estrogen, nto leyo eyenza ukuba ibe yeyona ndlela ikhuselekileyo.Ukuvela kwe-Raloxifene Hydrochloride njengendlela esebenzayo ekunyangeni ezinye iimeko zonyango ezifana ne-endometrial hyperplasia, isandulela somhlaza we-endometrial, kunye nokunciphisa umngcipheko weziganeko ze-cardiovascular kubafazi be-postmenopausal igxininisa ngakumbi amandla ayo ekuphuculeni impilo yabasetyhini ngokubanzi.
Ngamandla ayo amakhulu ekuphuculeni impilo yamathambo, ukuthintela umhlaza wamabele, kunye nokujongana nezinye iimeko ezinxulumeneyo, iRaloxifene Hydrochloride ikulungele ukuguqula ukhathalelo lwezempilo lwabasetyhini.Eli yeza litsha linika ithemba kwizigidi zabasetyhini kwihlabathi jikelele abajongene nemingeni enxulumene nesifo samathambo, umhlaza wamabele kunye neminye imiba yezempilo.Ukukwazi ukubonelela ngonyango olusebenzayo ngelixa kuncitshiswa iziphumo ezibi ezidla ngokunxulunyaniswa nonyango lokubuyisela ihomoni kuphawula impumelelo ebalulekileyo.
Njengoko abaqeqeshi bezempilo beqhubeka behlola izisombululo ezintsha, i-Raloxifene Hydrochloride ibonisa ixesha elitsha kwintsimi yempilo yabasetyhini.Eli nyango lothusayo alipheleli nje ekulungiseni iimeko ezixhaphakileyo kodwa likwavula indlela yokuqhubela phambili kunye neempumelelo.Izigulane kunye nababoneleli bezempilo banokulindela ngomdla ukuphuhliswa okuqhubekayo kunye nokusetyenziswa kwe-Raloxifene Hydrochloride njengesixhobo esibalulekileyo ekukhuthazeni impilo yabasetyhini kunye nokuphucula kakhulu umgangatho wobomi.
Ixesha lokuposa: Jul-08-2023