Uphononongo lwakutsha nje luveze ukuba amadoda afumana iinaliti ze testosterone undecanoate ezithatha ixesha elide kunokwenzeka ukuba abambelele kunyango lwazo xa kuthelekiswa nalawo afumana iinaliti ze testosterone propionate ezithatha ixesha elifutshane.Iziphumo ziqaqambisa ukubaluleka kweendlela ezifanelekileyo zonyango lwe testosterone ekuqinisekiseni ukuzibophelela kwesigulana kunyango.
Uphononongo, olubandakanya uhlalutyo lokubuyela emva kwedatha evela kumadoda angaphezu kwe-122,000 e-United States, xa kuthelekiswa amazinga okubambelela amadoda aphathwa nge-testosterone undecanoate kwabo baphathwa nge-testosterone cypionate.Iziphumo zabonisa ukuba kwiinyanga ezi-6 zokuqala zonyango, omabini amaqela anemilinganiselo efanayo yokubambelela kunyango.Nangona kunjalo, njengoko ixesha lonyango landiswa ukusuka kwi-7 ukuya kwiinyanga ze-12, kuphela i-8.2% yezigulane ezifumana i-testosterone cypionate eqhubekayo unyango, xa kuthelekiswa ne-41.9% ebalulekileyo yezigulane ezifumana i-testosterone undecanoate.
UDkt Abraham Morgenthaler, uprofesa oncedisayo wotyando kwisebe le-urology ye-Beth Israel Deaconess Medical Centre kwi-Harvard Medical School, ubonise ukubaluleka kwezi ziphumo.Wathi, "Ubungqina bubonisa ukuba iindlela ezilula ngakumbi zonyango lwe testosterone, ezifana nenaliti ezithatha ixesha elide, zibalulekile ekuzimiseleni kwamadoda anokusilela kwe testosterone ukuqhubeka nonyango."UDkt Morgenthaler ugxininise ukuqaphela okukhulayo kokusilela kwe testosterone njengemeko yempilo ebalulekileyo kwaye wagxininisa izibonelelo zezempilo ezibanzi ezinokuthi zibonelele ngonyango lwe-testosterone, kubandakanywa nokuphuculwa kokulawulwa kweswekile yegazi, ukunciphisa amanqatha, ukunyuka kwemisipha, ukuphuculwa kwemizwelo, ukuxinana kwamathambo, kunye nokunciphisa. ianemia.Nangona kunjalo, ukuqonda ezi zibonelelo kuxhomekeke ekugcineni ukubambelela kunyango.
Uphononongo, olwenziwa nguDkt. Morgenthaler kunye noogxa bakhe, basebenzise idatha evela kwi-database ye-Verdigm, eqokelela idatha yerekhodi yezempilo ye-elektroniki kwiindawo ezingaphandle kwe-United States.Abaphandi bagxininise kumadoda aneminyaka eyi-18 nangaphezulu abaye baqalisa unyango lwe-testosterone undecanoate okanye i-testosterone cypionate phakathi kwe-2014 kunye ne-2018. Idatha, eqokelelwe kwiinyanga ze-6 ukuya kuthi ga ngoJulayi 2019, ivumele abaphandi ukuba bahlole ukuthotyelwa konyango ngokusekelwe kwixesha lexesha. ukuqeshwa kunye naluphi na ukupheliswa, utshintsho olumiselweyo, okanye ukugqitywa konyango olumiselweyo lwe testosterone.
Ngokukodwa, ukuthotyelwa konyango kwiqela le-testosterone undecanoate kwachazwa njengesithuba esingaphezu kweentsuku ze-42 phakathi komhla wokugqibela wokuqeshwa kokuqala kunye nomhla wokuqala wokuqeshwa kwesibini, okanye isithuba seentsuku ze-105 phakathi kokuqeshwa okulandelayo.Kwiqela le testosterone cypionate, ukungathobeli kwachazwa njengethuba leentsuku ezingaphezu kwe-21 phakathi kokuqeshwa.Ukongeza kumazinga okubambelela, abaphandi bahlalutya izinto ezahlukeneyo ezifana nokutshintsha kobunzima bomzimba, i-BMI, uxinzelelo lwegazi, amanqanaba e-testosterone, amaxabiso eziganeko ezintsha ze-cardiovascular, kunye nemingcipheko echaphazelekayo esuka kwiinyanga ze-3 ngaphambi kokuba inaliti yokuqala kwiinyanga ze-12 emva kokuqala unyango.
Ezi zinto zifunyanisiweyo zisikhanyisela ngokubaluleka kweenaliti ze testosterone ezisebenza ixesha elide ekukhuthazeni ukubambelela kunyango kunye nokwandisa uncedo olunokubakho lonyango lwe testosterone.Amadoda anokusilela kwe testosterone anokuzuza kakhulu kwiindlela ezifanelekileyo zonyango, ukuqinisekisa ukuqhubeka kunye nokukhuthaza ukuzibophelela kwexesha elide ekuphuculeni impilo yabo kunye nokuphila kakuhle.
Ixesha lokuposa: Jul-07-2023