Iziphumo zophononongo zibonise ukuba amadoda afumana iinaliti ze-testosterone ze-undecanoate ezithatha ixesha elide zazibambelele ngakumbi kunyango emva konyaka we-1 kunamadoda afumana ii-injection ze-testosterone propionate ezimfutshane.
Uhlalutyo oluhlaziyiweyo lwedatha evela kumadoda angaphezu kwe-122,000 e-United States lubonise ukuba amadoda aphathwa nge-testosterone undecanoate (i-Aveed, i-Endo Pharmaceuticals) yayinamazinga afanayo okubambelela kwiinyanga zokuqala ze-6 zonyango njengamadoda aphathwa nge-testosterone cypionate.Amazinga okubambelela asuka kwi-7 ukuya kwiinyanga ze-12, kunye ne-8.2% kuphela yezigulane eziphathwe nge-testosterone cypionate eqhubekayo unyango lweenyanga ze-12 xa kuthelekiswa ne-41.9% yezigulane eziphathwe nge-testosterone undecanoate.
"Ubungqina bubonisa ukuba iindlela ezifanelekileyo ngakumbi zonyango lwe-testosterone, ezifana ne-injection esebenza ixesha elide, zibalulekile ekuthandeni kwamadoda ane-testosterone ukusilela ukuqhubeka nonyango," utshilo u-Abraham Morgenthaler, MD, uprofesa oncedisayo wotyando.U-Helio uthe usebenze kwisebe le-urology kwi-Beth Israel Deaconess Medical Centre kwi-Harvard Medical School."Kukho ukuqonda okukhulayo ukuba ukunqongophala kwe testosterone yimeko ebalulekileyo yempilo kwaye unyango lwe testosterone lunokuphucula kungekuphela nje iimpawu kodwa kunye neenzuzo zempilo jikelele ezifana nokuphuculwa kokulawula iswekile yegazi, ukunciphisa ubunzima bomzimba kunye nokwanda kwemisipha, isimo sengqondo, ukuxinana kwamathambo kunye nesizathu esingachazwanga. .ianemia.Nangona kunjalo, ezi zibonelelo zinokufumaneka kuphela ukuba amadoda abambelele kunyango. "
U-Morgenthaler kunye noogxa baqhube i-retrospective cohort yophando lwedatha evela kwi-database ye-Verdigm, equlethe idatha yerekhodi yezempilo ye-elektroniki evela kwi-US izigulane zangaphandle, kuquka abo baqala injectable testosterone undecanoate okanye i-testosterone cypionate phakathi kwe-2014 kunye ne-2018. Amadoda aneminyaka eyi-18 nangaphezulu.Idatha eqokelelwe kwiinyanga ze-6 ukunyuka ukususela ngoJulayi 2019. Unyango lwesondlo luchazwe njengekhefu phakathi kokuqeshwa okungazange kudlule kabini isithuba se-dosing esicetyiswayo seeveki ze-20 ze-testosterone undecanoate okanye iiveki ze-4 ze-testosterone cypionate.Ukubambelela kunyango kwavavanywa ukususela kumhla wokutofa inaliti yokuqala ukuya kumhla woyekwa, ukutshintshwa komyalelo kagqirha, okanye ukuphela konyango olumiselweyo lwe testosterone.I-Testosterone yokungahambelani neqela le-testosterone undecanoate yachazwa njengesithuba esingaphezu kweentsuku ze-42 phakathi komhla wokugqibela wokuqeshwa kokuqala kunye nomhla wokuqala wokuqeshwa kwesibini, okanye isithuba esingaphezu kweentsuku ze-105 phakathi kokuqeshwa kwexesha elizayo.Ukungabambeleli kwiqela le-testosterone cypionate kwachazwa njengekhefu leentsuku ezingaphezu kwe-21 phakathi kokuphela kokuqeshwa kunye nokuqala kokulandelayo.Abaphandi bavavanya utshintsho kwisisindo somzimba, i-BMI, uxinzelelo lwegazi, amanqanaba e-testosterone, amaxabiso eziganeko ezintsha ze-cardiovascular, kunye nemingcipheko evela kwiinyanga ze-3 ngaphambi kokuba inaliti yokuqala kwiinyanga ze-12 emva kokuqala kwonyango.
Iqela lokufunda lalinamadoda angama-948 athatha i-testosterone undecanoate kunye namadoda angama-121,852 athatha i-testosterone cypionate.Kwisiseko, i-18.9% yamadoda kwiqela le-testosterone undecanoate kunye ne-41.2% yamadoda kwiqela le-testosterone cypionate ayinalo ukuxilongwa kwe-hypogonadism.Ithetha i-testosterone yamahhala kwisiseko yayiphezulu kwizigulane ezithatha i-testosterone undecanoate xa kuthelekiswa nalabo bathatha i-testosterone cypionate (65.2 pg/mL vs 38.8 pg/mL; P <0.001).
Ngexesha leenyanga ezi-6 zokuqala, amazinga okubambelela kunyango ayefana kuwo omabini amaqela.Ngexesha le-7 ukuya kwiinyanga ze-12, iqela le-testosterone undecanoate linezinga eliphezulu lokubambelela kuneqela le-testosterone cypionate (82% vs 40.8%; P <0.001).Xa kuthelekiswa neenyanga ze-12, inani eliphezulu lamadoda kwiqela le-testosterone undecanoate laqhubeka nonyango lwe-testosterone olungenangqondo (41.9% vs 0.89.9%; P <0.001).Amadoda athatha i-testosterone cypionate.
Okumangalisayo kukuba, kuphela ipesenti ze-8.2 zamadoda afake i-testosterone cypionate eqhubeka nonyango emva kwe-1 unyaka," kusho uMorgenthaler."Ixabiso eliphantsi kakhulu lonyango lwe testosterone olusetyenziswa ngokuqhelekileyo eUnited States lithetha ukuba amadoda aswele i-testosterone akaphathwa kakuhle."
Izigulane eziphathwe nge-testosterone undecanoate zineenguqu ezinkulu kwi-testosterone epheleleyo (171.7 ng / dl vs 59.6 ng / dl; P <0.001) kunye ne-testosterone yamahhala (25.4 pg / ml vs 3.7 pg / ml; P = 0.001).Ukunyuka kweenyanga ze-12 xa kuthelekiswa nezigulane eziphathwe nge-testosterone cypionate.I-Testosterone undecanoate ibonise ukuhluka okuncinci kumanqanaba apheleleyo e-testosterone kune-testosterone cypionate.
Kwiinyanga ze-12, utshintsho oluchanekileyo kwisisindo, i-BMI, kunye noxinzelelo lwegazi lwalufana phakathi kwamaqela.Iqela le-testosterone undecanoate lalinomlinganiselo ophezulu wamadoda ane-erectile dysfunction esanda kuxilongwa kunye nokukhuluphala ekulandeleni, ngelixa iqela le-testosterone cypionate linenani eliphezulu lamadoda afunyanwe enoxinzelelo lwegazi, ukungaphumeleli kwentliziyo, kunye neentlungu ezingapheliyo.
Uphando olongezelelweyo luyafuneka ukuqonda ukuba kutheni amadoda amaninzi afaka i-testosterone cypionate ayeke unyango phakathi konyaka, uMorgenthaler uthi.
"Sinokucinga ukuba kolu phononongo, i-testosterone undecanoate isetyenziswe kwixabiso eliphezulu kakhulu kwiinyanga ze-12 ngenxa yokulungelelaniswa kweyeza elide, kodwa ukubona ukuba oku kubangelwa ezinye izinto (ezifana neendleko), ukuchaswa kweyeza. iinaliti zokuzinyanga rhoqo, ukungabikho kophuculo olubonakalayo kwiimpawu, okanye ezinye izizathu, ”utshilo uMorgenthaler.
Ixesha lokuposa: Jul-05-2023